Kickoff Date: Thursday, July 31, 2025
Time: 8:00 PM ET
Venue: Tom Benson Hall of Fame Stadium, Canton, Ohio
Occasion: 2025 NFL Preseason Opener – Hall of Fame Game
Featured Enshrinement: Antonio Gates (Chargers TE Legend)
Introduction
The NFL is back—and it kicks off in grand style with the 2025 Hall of Fame Game, featuring the Los Angeles Chargers and Detroit Lions. Set against the historic backdrop of Canton, Ohio, the matchup marks the official start of preseason and a symbolic celebration of NFL greatness.
This year’s clash is especially meaningful for the Chargers, with their legendary tight end Antonio Gates being inducted into the Pro Football Hall of Fame. It’s a reunion of legacy and future ambition, as both teams set the tone for the upcoming season.
In this detailed Chargers vs Lions 2025 preview, we’ll break down likely lineups, player matchups, coaching insights, betting predictions, and give you our final score prediction.
🔍 Chargers vs Lions – What’s at Stake?
While this is a preseason game, it sets the tone for two franchises with high expectations:
- The Lions are coming off an NFL-best 15–2 regular season and are targeting a Super Bowl push under Dan Campbell.
- The Chargers, under the leadership of Jim Harbaugh, are developing a new identity rooted in physicality and defense.
Both sides will limit their starters, so this is a golden opportunity for rookies and fringe players to make an impression.
🦁 Detroit Lions 2025 Preview
2024 Recap
The Lions shocked the league last season by finishing 15–2, earning the top seed in the NFC. Under head coach Dan Campbell, they played tough, physical football and leaned on a strong offensive line and aggressive defensive front.
Key Players
- Jared Goff (QB): While Goff will likely sit, he remains the undisputed starter.
- Hendon Hooker (QB2): All eyes are on the second-year quarterback out of Tennessee, expected to get the bulk of preseason snaps.
- Jahmyr Gibbs & David Montgomery (RB): One of the best RB duos in football. Expect light usage in the HOF game, with Craig Reynolds and Sione Vaki seeing more action.
- Amon-Ra St. Brown, Jameson Williams (WRs): Expect them to start hot in 2025, but unlikely to play much on Thursday.
Defense to Watch
- Aidan Hutchinson (DE): Emerging superstar who will likely play limited snaps.
- Tyleik Williams (DT, Rookie): A high-upside addition, expected to battle for starting reps.
- Edge rotation: Look out for players like Marcus Davenport and Keith Cooper Jr. competing for backup reps.
Lions Roster Focus
Detroit will likely evaluate depth across:
- Interior DL, due to injuries to Alim McNeill and Levi Onwuzurike
- Wide receiver depth, including rookie Isaac TeSlaa
- OL rotation, anchored by veterans but needing young depth to step up
⚡ Los Angeles Chargers 2025 Preview
2024 Season Recap
The Chargers went 11–6 in Harbaugh’s first season, returning to the playoffs. Known for their power-run game and aggressive defense, the Bolts are entering a new phase without stars like Joey Bosa, released earlier in 2025.
Key Players
- Justin Herbert (QB): Franchise QB; expect him to be sidelined for most (if not all) of this game.
- DJ Uiagalelei (QB): Undrafted rookie from Oregon State, likely to lead the offense on Thursday.
- Omarion Hampton (RB, 1st Round): Look for the rookie to get major touches in his debut.
- Tre Harris (WR, 2nd Round): The vertical threat from Ole Miss will aim to connect with Uiagalelei.
Defense to Watch
- Naquan Jones (DT): Anchoring the defensive interior.
- Edge rushers: With Bosa gone, younger players like Chris Rumph II will have a shot to shine.
- Defensive backs: Several UDFA CBs and safeties will be fighting for depth chart position.
Chargers Roster Focus
Position battles include:
- Backup QB: Uiagalelei vs Easton Stick
- RB3 spot: Raheim Sanders vs Isaiah Spiller
- Edge and LB depth
- OL backups, including 2024 pick Karsen Barnhart
🧠 Coaching & Tactical Breakdown
Jim Harbaugh (Chargers)
- Emphasizes smashmouth football, zone running, and physical defense.
- Likely to keep game plan simple—lots of inside runs and quick throws.
- Wants to test rookie stamina, especially from Hampton and Harris.
Dan Campbell (Lions)
- Always passionate, but more conservative in preseason.
- Will want to see Hooker’s development and whether younger defensive linemen can stop the run.
- WR group under scrutiny due to WR4/WR5 battles.
🎯 Game Plan Prediction
Chargers Game Plan
- Heavy run focus: Omarion Hampton and backup RBs to get 20–25 carries total.
- Deep shots to Tre Harris, trying to test Lions’ backup corners.
- Uiagalelei will have freedom to scramble and use RPO looks.
Lions Game Plan
- Hooker-centric offense: Building chemistry with young WRs.
- Short passing game, designed to boost Hooker’s rhythm and accuracy.
- Defensive scheme will rotate edge players and test interior depth.
📈 Betting Odds & Line Movement
According to SCCG Management and BetMGM:
- Spread: Lions –3.5
- Over/Under: 33.5 points
- Moneyline: Lions –175 / Chargers +150
Best Bets:
- ✅ Under 33.5 points – Preseason games are typically slow-paced
- ✅ Lions ML – Slight edge due to QB depth and roster depth
- 🚫 Avoid props due to unpredictable rotations
📝 Chargers vs Lions Prediction
Expert Score Predictions:
- SCCG Management: Lions 16, Chargers 10
- Cappers Picks: Lions 17, Chargers 13
- Betimate: Lions 14, Chargers 13
Our Final Prediction:
Detroit Lions 14 – Los Angeles Chargers 10
Expect a low-scoring, grinder-style game dominated by running and defense. Both teams will evaluate key position groups, but Lions have more experienced depth, especially at QB and WR. Hooker leads a solid opening TD drive, while the Chargers struggle to sustain offense despite flashes from Omarion Hampton.
📸 Players to Watch
Team | Offense Highlight | Defense Highlight |
---|---|---|
Lions | Hendon Hooker (QB) | Tyleik Williams (DT) |
Chargers | Omarion Hampton (RB) | Naquan Jones (DT) |
Both Teams | Tre Harris (WR, LAC) | Keith Cooper Jr. (Edge, DET) |
🏁 Final Thoughts
Though technically “just” a preseason game, the 2025 Hall of Fame Game carries real significance. It’s a celebration of legends like Antonio Gates, and it’s the first chance for fans and coaches alike to gauge the health, depth, and energy of their teams.
The Chargers enter with a fresh identity under Jim Harbaugh, while the Lions are looking to prove last year’s 15–2 season wasn’t a fluke.
In what should be a tightly contested, hard-fought matchup, expect Detroit to come out on top—thanks to superior depth, experience, and a strong preseason philosophy under Dan Campbell.
Final Score: 🦁 Lions 14 – ⚡ Chargers 10